oxaliplatin but not irinotecan impairs posthepatectomy liver regeneration in a murine model
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2011
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Abstract
Introduction. We examined the murine hepatectomy model of liver regeneration (LR) in the setting of neoadjuvant chemotherapy. Methods. C57BL/6 mice were randomized to receive neoadjuvant intraperitoneal (IP) injections of a control, oxaliplatin (15 mg/kg), or irinotecan (100 mg/Kg or 250 mg/Kg) solution. Hepatectomy (70%) was performed 14 days after the final IP treatment. Animals were sacrificed at postoperative day (D) 0, 1, 2, 3, and 7. Liver remnants and serum were collected for analysis. 𝑇-tests for independent samples were used for statistical comparisons. Results. For oxaliplatin, percent LR did not differ at D1 or D2 but was significantly less at D3 (89.0% versus 70.0%, 𝑃=0.048) with no difference on D7 (𝑃=0.21). Irinotecan-treated mice at both dose levels (100 mg/Kg and 250 mg/Kg) showed no significant differences in LR. BrdU incorporation was significantly decreased in oxaliplatin-treated animals (D1,2,3). Conclusions. Neoadjuvant oxaliplatin but not irinotecan impairs early LR in a posthepatectomy murine model which correlates with decreased DNA synthesis.
| Reference Key |
soriano2011internationaloxaliplatin
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|---|---|
| Authors | ;Perry A. Soriano;Nian Liu;Erick Castillo;Brock Foster;Avo Artinyan;Joseph Kim;Wendong Huang;Lawrence D. Wagman |
| Journal | harbin gongye daxue xuebao/journal of harbin institute of technology |
| Year | 2011 |
| DOI |
10.4061/2011/490463
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| URL | |
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