hypericum triquetrifolium—derived factors downregulate the production levels of lps-induced nitric oxide and tumor necrosis factor-α in thp-1 cells

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ID: 176275
2011
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Abstract
Based on knowledge from traditional Arab herbal medicine, this in vitro study aims to examine the anti-inflammatory mechanism of Hypericum triquetrifolium by measuring the expression and release of pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukine-6 (IL-6), and inducible nitric oxide synthase (iNOS) in human monocytic cells, THP-1. The effects were assessed by measuring the levels of secretory proteins and mRNA of TNF-α and IL-6, the levels of nitric oxide (NO) secretion and the expression of iNOS in THP-1 cells. Cells were treated with 5 μg lipopolysaccharide/ml (LPS) in the presence and absence of increasing concentrations of extracts from the aerial parts of H. triquetrifolium. During the entire experimental period, we used extract concentrations (up to 250 μg mL−1) that had no cytotoxic effects, as measured with MTT and LDH assays. Hypericum triquetrifolium extracts remarkably suppressed the LPS-induced NO release, significantly attenuated the LPS-induced transcription of iNOS and inhibited in a dose-dependent manner the expression and release of TNF-α. No significant effects were observed on the release of IL-6. Taken together, these results suggest that H. triquetrifolium probably exerts anti-inflammatory effects through the suppression of TNF-α and iNOS expressions.
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saad2011evidence-basedhypericum Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Bashar Saad;Bernadette Soudah AbouAtta;Walid Basha;Alaa Hmade;Abdalsalam Kmail;Said Khasib;Omar Said
Journal ACS applied materials & interfaces
Year 2011
DOI
10.1093/ecam/nen056
URL
http://dx.doi.org/10.1093/ecam/nen056
Keywords
Other systems of medicine

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