optimization of solid-phase synthesis of polyamide nucleic acid mimetics with application of maldi-tof mass-spectrometry
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ID: 176019
2013
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Abstract
The solid-phase synthesis of a tetrameric model sequence of polyamide nucleic acid mimetics (PANAM) incorporating terminal chiral and charged unit was performed. As a result during the synthesis and cleavage from the resin the tendency of PANAM with the N-terminal negatively charged monomer to cyclization with simultaneous N-acyl transfer of carboxyethyl base residue was found. Application of MALDI-TOF mass - spectrometry allowed us to find suitable conditions for obtaining PANAM oligomers without the significant amount of by-products.
| Reference Key |
shirayeva2013optimization
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| Authors | ;M. V. Shirayeva;Yu. G. Kirillova;E. D. Nikol’Skaya;D. I. Prokhorov;I. P. Smirnov;G. E. Pozmogova |
| Journal | indian journal of community medicine |
| Year | 2013 |
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| Keywords | Keywords not found |
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