analysis of association between tlr-4 asp299gly and thr399ile gene polymorphisms and chronic periodontitis in a sample of south indian population
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2011
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Abstract
Background: To analyze the association between TLR-4 Asp299Gly and Thr399Ile gene polymorphisms and chronic periodontitis in a sample of south Indian population. Materials and Methods: Genomic DNA was obtained from peripheral blood of 60 patients with chronic periodontitis and 60 periodontally healthy subjects. TLR-4 Asp299Gly and Thr399Ile gene polymorphisms were genotyped by a polymerase chain reaction-restriction fragment length polymorphism method. The data were analyzed by a χ2-test and by relative risk estimation. Results: Thr399Ile alleles were found in 4% of chronic periodontitis patients and in 1% of periodontally healthy subjects. The prevalence of a Thr399Ile heterozygote was found to be 5% in the chronic periodontitis group and 1.67% in the periodontally healthy group, respectively. Homozygosity for TLR-4 Thr399Ile was seen in chronic periodontitis patients only, which was 1.67%. The TLR-4 Asp299Gly gene polymorphism was not detected in either chronic periodontitis or periodontally healthy groups. Conclusion: There is no significant association between TLR-4 Thr399Ile polymorphism and chronic periodontitis in a sample of south Indian population.
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reddy2011journalanalysis
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| Authors | ;Bavigadda Harish Reddy;N D Jayakumar;Sreenivasa Rao Akula;Rupali Sharma;G Kaarthikeyan;Sankari |
| Journal | metallomics : integrated biometal science |
| Year | 2011 |
| DOI |
10.4103/0972-124X.92571
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