association of electroretinogram and morphological findings in central retinal vein occlusion with macular edema

Hidetaka Noma1, Tatsuya Mimura2, Manami Kuse3,4, Katsunori Shimada51Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan; 2Department of Ophthalmology, Medical Center East, Tokyo Women's Medical University, Tokyo, Japan; 3Department of Ophthalmology, National Hospital Organization, Mie Central Medical Center, Tsu, Japan; 4Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan; 5Department of Biostatistics, STATZ Institute Inc., Tokyo, JapanAbstract: The objective of this study was to evaluate the relations among electroretinogram (ERG) parameters (cone a-wave, cone b-wave, and 30 Hz flicker), retinal thickness, and retinal volume in 16 patients with central retinal vein occlusion and macular edema. The amplitude and implicit time of the ERG parameters were extracted from the ERG traces. Retinal thickness and volume were measured by optical coherence tomography in nine macular subfields. Then the correlations among ERG parameters and morphological parameters were analyzed. The cone b-wave and 30 Hz flicker implicit time were correlated with retinal thickness and volume in seven out of nine subfields, excluding the temporal subfields. In addition, the amplitude of the cone b-wave was correlated with retinal thickness and volume in the nasal inner and nasal outer subfields. These findings suggest that retinal thickness and volume may be associated with outer and inner retinal function in central retinal vein occlusion patients.Keywords: central retinal vein occlusion, electroretinogram, macular edema, optical coherence tomography