concurrent treatment with tamoxifen and cyp2d6 inibitors: clinical significance of drug interactions
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ID: 175799
2012
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Abstract
Tamoxifen is used in the treatment of women
with endocrine responsive breast cancer. It is a
prodrug, which is metabolized by liver cytochrome
P450 system (CYP) into metabolites
with a potent anti-estrogenic activity; CYP2D6
is one of the most important enzymes involved
in this metabolic pathway. Low or absent activity
of CYP2D6, which can be inherited and/or
can occur due to the use of CYP2D6 inhibitors,
may impair outcome in women with tamoxifentreated
breast cancer. Antidepressants, which can
also inhibit CYP2D6, are among the most commonly
prescribed drugs in women with breast
cancer. Breast cancer patients receiving tamoxifen
should not be co-prescribed antidepressants
or any other drugs, which are potent inhibitors
of CYP2D6.
| Reference Key |
eruga2012zdravnikiconcurrent
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|---|---|
| Authors | ;Boštjan Šeruga;Brigita Novak Šarotar;Lea Knez;Simona Borštnar;Rado Janša;Marga Kocmur;Tanja Čufer |
| Journal | planta medica |
| Year | 2012 |
| DOI |
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| URL | |
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