Enhanced l-Lysine into 1,5-Diaminopentane Conversion via Statistical Optimization of Whole-Cell Decarboxylation System.

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ID: 17576
2019
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Abstract
The global lysine companies in the feed industry have steadily built their production facilities due to the high demand for l-lysine in animal farms, and in recent years there have been excessive supply problems and the world market price of l-lysine has fallen. In this study, the conversion of 1,5-diaminopentane (DAP) by decarboxylation of l-lysine was strategically chosen to enhance the value of lysine. The decarboxylation is enzymatically accessible, and , which is the producer of l-lysine decarboxylase, was applied as a whole-cell form. In the designed whole-cell biocatalytic system, the major four reaction factors were selected by fundamental investigation and then statistical optimization was performed to estimate the optimum condition. The predicted conversion was assessed at about 94.6% at the optimum conditions (125.1 mM l-lysine and 71.5 g/L acetone concentration at 35.2 °C for 8.4 h). Under the determined conditions, DAP conversions by using analytical, feed and industrial crude l-lysine were found to be 98.3%, 92.5% and 72.4%, respectively. These results could be suggested to solve the problem of excessive supplied lysine and also to provide guidance for improved enzymatic conversion by statistical optimization.
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kim2019enhancedpolymers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kim, Hanyong;Yoo, Hah Young;Park, Nohseong;Kim, Haeun;Lee, Jongwha;Baek, Yesol;Lee, Taek;Oh, Jong-Min;Cho, Jaehoon;Park, Chulhwan;
Journal Polymers
Year 2019
DOI
E1372
URL
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