contraceptive effect of uncaria tomentosa (cat's claw) in rats with experimental endometriosis efeito anticoncepcional da uncaria tomentosa (unha-de-gato) em ratas com endometriose experimental

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ID: 175709
2011
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Abstract
PURPOSE: Evaluate the histological changes in parenchyma´s epithelial layer of the uterus and ovarian of rats with induced endometriosis, treated with Uncaria tomentosa extract. METHODS: 29 rats with experimental endometriosis, were selected and divided in three groups: The uncaria group received 32mg/ml of Uncaria tomentosa extract, 1ml administered daily and the placebo group received 1ml of saline 0.9% per day, during for 14 days (both groups); the leuprolide group received leuprolide acetate 1mg/kg body weight applied single subcutaneous dose. In the 15th day of treatment the uterine horn and ovaries were removed for histopathological analysis. RESULTS: The uncaria group presented nine samples (90%) with immature ovarian follicles, whereas the placebo group did not present any case and in the leuprolide group there were eight rats (88%) with the same change. The placebo group showed mature corpus luteum in all animals, occurring less frequent in uncaria (10%) and leuprolide (22%) groups. The uterine epithelium showed weak proliferative in nine (90%) samples of the uncaria group, in two (20%) animals in the placebo group and seven (77.8%) rats in the leuprolide group. CONCLUSIONS: The findings suggest that Uncaria tomentosa has contraceptive effect.
OBJETIVO: Avaliação histológica do útero e parênquima ovariano de ratas com endometriose induzida tratadas com extrato de Uncaria tomentosa. MÉTODOS: Foram selecionadas 29 ratas com endometriose experimental e formados três grupos: O grupo uncaria recebeu extrato de Uncaria tomentosa com 32mg/ml, administrado 1ml ao dia e o grupo placebo recebeu 1ml de solução salina a 0,9%, ambos por 14 dias; o grupo leuprolida recebeu acetato de leuprolida 1mg/kg de peso corporal aplicado via subcutânea dose única. No 15° dia de tratamento realizou-se retirada de corno uterino e ovários para análise histopatológica. RESULTADOS: O grupo uncaria apresentou nove amostras (90%) com maturação incompleta dos folículos ovarianos, já o grupo placebo não apresentou nenhum caso e no grupo leuprolida houve oito ratas (88%) com a mesma alteração. O grupo placebo apresentou corpo lúteo maduro em todos os animais, acontecendo de forma menos freqüente nos grupos uncaria (10%) e leuprolida (22%). O epitélio uterino se mostrou fracamente proliferativo em nove (90%) das amostras do grupo unacaria, em dois (20%) casos do grupo placebo e sete (77.8%) casos no grupo leuprolida. CONCLUSÃO: Os achados sugerem que a Uncaria tomentosa tem efeito anticoncepcional.
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neto2011actacontraceptive Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;João Nogueira Neto;Frederico Lucas Lima Paiva Cavalcante;Rafael Antonio Freire Carvalho;Taciana Gabrielle Pinheiro de Moura Rodrigues;Mariana Santana Xavier;Pablo Gustavo Ribeiro Furtado;Eduardo Schor
Journal forensic science international
Year 2011
DOI
10.1590/S0102-86502011000800004
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000800004
Keywords
endometriosis contraception phytotherapy ratssurgery

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