traditional herbal medicine-derived sulforaphene lfs-01 reverses colitis in mice by selectively altering the gut microbiota and promoting intestinal gamma-delta t cells
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2018
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Abstract
Sulforaphene (LFS-01) is a natural compound derived from traditional herbal medicine. Here, we show that oral administration of LFS-01 is able to dramatically alter the skewed gut microbiota and reverse colitis in model mice associated with an increase of intestinal γδT cells. Through 16S rDNA sequencing, we showed that LFS-01 can selectively suppress enteric pathogens such as Escherichia–Shigella and Helicobacter whereas the protective strains including Lactobacillus and Lachnospiraceae were significantly expanded after LFS-01 treatment. Interestingly, we demonstrated that LFS-01 administration can significantly promote the IL-17+γδT cells in model mice in response to the expanded Lactobacillus. We verified that the intracellular components of Lactobacillus can stimulate the growth of IL-17+γδT cells upon preincubation. The increased IL-17A after LFS-01 treatment in turn recovers the disrupted occludin subcellular location and protects the epithelial barrier in the colon of model mice. Remarkably, LFS-01 does not show apparent toxicity to animals and we demonstrated that LFS-01 also exerts strong protective effects in TNBS-induced colitis rats. Therefore, LFS-01 holds great promise for the treatment of inflammatory bowel disease (IBD) and warrants translation for use in clinical trials. Our work provided a new avenue for the treatment of IBD based on the strategy of harnessing intestinal symbiosis.
| Reference Key |
li2018frontierstraditional
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| Authors | ;Ming Li;Jiali Gao;Yan Tang;Meishuo Liu;Sijin Wu;Kunli Qu;Xiangyu Long;Huajun Li;Min Liu;Yinhui Liu;Jieli Yuan;Lei Mao;Yu Liu;Xiliang Zheng;Erkang Wang;Jin Wang;Jin Wang;Yongliang Yang |
| Journal | chemical research in chinese universities |
| Year | 2018 |
| DOI |
10.3389/fphar.2017.00959
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| URL | |
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