an efficient chemoenzymatic approach towards the synthesis of rugulactone

نهج كيميائي إنزيمي فعال نحو تخليق الروغولاكتون

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ID: 175308
2018
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Abstract
Rugulactone is a natural product isolated from the plant Cryptocarya rugulosa. It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent ketoreductase, is described in detail.
يُعدّ الروجولاكتون ناتجاً طبيعياً معزولاً من نبات *Cryptocarya rugulosa*، وقد أظهر فاعلية حيوية بالغة الأهمية بوصفه مثبّطاً لمسار تنشيط العامل النووي كابا ب (NF-κB). يُقدَّم هنا نهجٌ كيميائي-إنزيمي جديد لتخليق الروجولاكتون، مع وصفٍ تفصيلي للكيرالية المُستحثة في المركّب الوسيط الرئيسي عبر اختزالٍ إنزيمي انتقائي فراغياً باستخدام إنزيم الكيتوريدوكتاز المعتمد على NADPH.
Reference Key
tyrikos-ergas2018moleculesan Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Theodore Tyrikos-Ergas;Vasileios Giannopoulos;Ioulia Smonou
Journal Journal of ethnopharmacology
Year 2018
DOI
10.3390/molecules23030640
URL
http://www.mdpi.com/1420-3049/23/3/640
Keywords
bioreduction

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