an efficient chemoenzymatic approach towards the synthesis of rugulactone
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ID: 175308
2018
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Abstract
Rugulactone is a natural product isolated from the plant Cryptocarya rugulosa. It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent ketoreductase, is described in detail.
| Reference Key |
tyrikos-ergas2018moleculesan
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|---|---|
| Authors | ;Theodore Tyrikos-Ergas;Vasileios Giannopoulos;Ioulia Smonou |
| Journal | Journal of ethnopharmacology |
| Year | 2018 |
| DOI |
10.3390/molecules23030640
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| URL | |
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