elusive treatment for human rhinosporidiosis
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ID: 175163
2016
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Abstract
Objectives: The aim of this study was to clarify the contentious taxonomic classification of Rhinosporidium seeberi, the cause of human rhinosporidiosis, which may have treatment implications.
Methods: PCR was used to amplify the internal transcribed spacer (ITS)-2 region from the genomic DNA of the aetiological agent obtained from a sample of human rhinosporidiosis lesions. The amplicon was sequenced and the organism identified using the Basic Local Alignment Search Tools (BLAST).
Results: Phylogenetic analysis revealed that the aetiological agent clustered along with the R. seeberi isolated from humans and also with Amphibiocystidium ranae from frogs. This organism is a member of the order Dermocystida in the class Mesomycetozoea. A patient with disseminated rhinosporidiosis did not respond to conventional therapy with dapsone and surgical excision, and treatment with amphotericin B also proved futile.
Conclusion: An effective treatment for R. seeberi—a eukaryote belonging to the class Mesomycetozoea—is still elusive.
| Reference Key |
janardhanan2016internationalelusive
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|---|---|
| Authors | ;Jeshina Janardhanan;Shalom Patole;Lalee Varghese;V. Rupa;Amit Jiwan Tirkey;George M. Varghese |
| Journal | israel journal of chemistry |
| Year | 2016 |
| DOI |
10.1016/j.ijid.2016.04.013
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| URL | |
| Keywords | Keywords not found |
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