a comparative study of psoriasis and psoriasiform lesion on basis of cd4 and cd8 cell infiltration

Clicks: 244
ID: 174862
2012
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Abstract
Introduction: Psoriasis is a chronic inflammatory skin disorder with immunological factors playing an important role in its pathogenesis. It is now regarded as a T cell mediated disorder in which lymphocytic infiltrates, mainly CD4 and CD 8 cells which provide a major contribution in the initiation and maintenance of psoriatic lesions.Methods: Skin biopsies from both psoriatic and psoriasiform lesions were stained with monoclonal antibodies against CD4 and CD8 and their percentage was calculated in the epidermis, upper dermis and lower dermis.Results: The difference of mean value of percentage of CD4 cells, among psoriasis and psoriasiform lesion in the epidermis was statistically insignificant(p=0.228), while it was significant in the upper dermis (p=0.002) and in lower dermis (p=0.043). The difference in the value of percentage of CD 8 cells was statistically significant in the epidermis(p=0.007), upper dermis (p=0.005), and the lower dermis (p=0.043)Conclusion: Both CD4 and CD 8 T cells are present in the appropriate anatomic locations to sustain lesional skin pathology in psoriasis and psoriasiform lesions.
Reference Key
rana2012naszaa Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Safia Rana;Jairajpuri Shamim Zeeba;Jetley Sujata;Kudesia Madhur
Journal european journal of integrative medicine
Year 2012
DOI
DOI not found
URL
http://www.odermatol.com/2012-4-1-comparative-study-psoriasis/
Keywords
psoriasis cd4 cd8dermatology

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