synthesis and in vitro antimicrobial evaluation of new n-heterocyclic diquaternary pyridinium compounds
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ID: 174596
2014
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Abstract
A series of bis-pyridinium quaternary ammonium salts (bis-PyQAs) with different aryl and heteroaryl moieties were synthesized and their antimicrobial activity investigated. The inhibition effect of the compounds was evaluated against bacteria, molds and yeasts; the activities were expressed as the minimum inhibitory concentrations (MIC). The relationships between the structure descriptors (logP, polarizability, polar surface area (2D), van der Waals area (3D)) and the biological activity of the tested bis-PyQAs are discussed.
| Reference Key |
furdui2014moleculessynthesis
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|---|---|
| Authors | ;Bianca Furdui;Georgiana Parfene;Ioana Otilia Ghinea;Rodica Mihaela Dinica;Gabriela Bahrim;Martine Demeunynck |
| Journal | Journal of ethnopharmacology |
| Year | 2014 |
| DOI |
10.3390/molecules190811572
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| URL | |
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