spatiotemporal quantification of local drug delivery using mri

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ID: 174166
2013
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Abstract
Controlled release formulations for local, in vivo drug delivery are of growing interest to device manufacturers, research scientists, and clinicians; however, most research characterizing controlled release formulations occurs in vitro because the spatial and temporal distribution of drug delivery is difficult to measure in vivo. In this work, in vivo magnetic resonance imaging (MRI) of local drug delivery was performed to visualize and quantify the time resolved distribution of MRI contrast agents. Three-dimensional maps (generated from -weighted images with varied ) were processed using noise-reducing filtering. A segmented region of contrast, from a thresholded image, was converted to concentration maps using the equation , where and are the precontrast and postcontrast map values, respectively. In this technique, a uniform estimated value for was used. Error estimations were performed for each step. The practical usefulness of this method was assessed using comparisons between devices located in different locations both with and without contrast. The method using a uniform , requiring no registration of pre- and postcontrast image volumes, was compared to a method using either affine or deformation registrations.
Reference Key
giers2013computationalspatiotemporal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Morgan B. Giers, Alex C. McLaren, Jonathan D. Plasencia, David Frakes, Ryan McLemore, Michael R. Caplan
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Journal advanced functional materials
Year 2013
DOI
10.1155/2013/149608
URL
http://dx.doi.org/10.1155/2013/149608
Keywords
medical informatics computer applications to medicine

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