tumor-activated tcrγδ+ t cells from gastric cancer patients induce the antitumor immune response of tcrαβ+ t cells via their antigen-presenting cell-like effects
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2014
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Abstract
Human γδ T cells display the principal characteristics of professional antigen-presenting cells (APCs), in addition to playing a vital role in immunity through cytokine secretion and their cytotoxic activity. However, it is not clear whether γδ T cells perform APC-like functions under pathological conditions. In this study, we showed that, in contrast to peripheral-derived γδ T cells directly isolated from PBMCs of gastric cancer patients, tumor-activated γδ T cells not only killed tumor cells efficiently but also strongly induced primary CD4+ and CD8+ αβ T cells proliferation and differentiation. More importantly, they abrogated the immunosuppression induced by CD4+CD25+ Treg cells and induced the cytotoxic function of CD8+ αβ T cells from patients with gastric cancer. In conclusion, tumor-activated γδ T cells can induce adaptive immune responses through their APC-like functions, and these cells may be a potentially useful tool in the development of tumor vaccines and immunotherapy.
| Reference Key |
mao2014journaltumor-activated
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|---|---|
| Authors | ;Chaoming Mao;Xiao Mou;Yuepeng Zhou;Guoyue Yuan;Chengcheng Xu;Hongli Liu;Tingting Zheng;Jia Tong;Shengjun Wang;Deyu Chen |
| Journal | journal of photochemistry and photobiology b, biology |
| Year | 2014 |
| DOI |
10.1155/2014/593562
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| URL | |
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