antipyretic and antinociceptive activity of diospyros lotus l. in animals

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ID: 173778
2014
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Abstract
Objective: To evaluate pharmacologically the traditional use of Diospyros lotus as antipyretic and antinociceptive in various animal models. Methods: In vivo experimental models were used in this study. Antipyretic activity of extract/fractions was evaluated in brewer's yeast induced hyperthermic mice while antinociceptive activity was studied in acetic acid induced writhing test at 50 and 100 mg/kg i.p. Results: The crude extract strongly ameliorated the induced pyrexia during various assessment times. Upon fractionation, the antipyretic effects were strongly augmented by the chloroform and ethyl acetate fractions of the plant. However, hexane and butanol fractions were insignificant in their effect as antipyretic. The extract showed marked inhibition on the noxious simulation induced by post acetic acid injection. The effect was strongly supported by other fraction expect hexane. Conclusions: In short, our study scientifically validated the traditional use of the plant as antipyretic.
Reference Key
rauf2014asianantipyretic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Abdur Rauf;Ghias Uddin;Bina S. Siddiqui;Naveed Muhammad;Haroon Khan
Journal Organic letters
Year 2014
DOI
10.12980/APJTB.4.2014C1020
URL
http://www.sciencedirect.com/science/article/pii/S2221169115302999
Keywords
tropical medicinebiology (general)

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