therapeutic depletion of iron stores is not associated with a reduced hemoglobin mass in a hemochromatosis patient

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ID: 172884
2016
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Abstract
Introduction: Hereditary hemochromatosis features a dysregulated iron absorption leading to iron overload and organ damage. The regulation of total hemoglobin mass during depletion of iron deposits by therapeutic phlebotomy has not been studied. Case Presentation: The initial ferritin level of the 52-year-old male subject was 1,276 μg/l. Despite successful depletion of iron stores (ferritinmin: 53 μg/l) through phlebotomies, total hemoglobin mass stabilized at the pretherapy level. However, regeneration of total hemoglobin mass was accelerated (up to 10.8 g/day). Conclusion: In this hemochromatosis patient, the total hemoglobin mass was not altered in the long term, but regeneration was accelerated, possibly due to elevated body iron content.
Reference Key
wrobel2016casetherapeutic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nina Wrobel;Torben Pottgiesser;Philipp Birkner;Peter Deibert;Christoph Ahlgrim
Journal trends in genetics : tig
Year 2016
DOI
10.1159/000448133
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