eficácia e tolerância do nitrofurfurilidene (1) na fase crônica da moléstia de chagas
Clicks: 16
ID: 172815
1974
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Popular Article
4.5
/100
16 views
7 readers
AI Quality Assessment
Not analyzed
Readership in this journal
PopularRanked #247 of 272 articles by views in mobile information systems
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 272 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Foram selecionados 25 pacientes chagásicos crônicos que apresentavam sorologia positiva e elevada parasitemia. A 15 deles, durante 120 dias, foi ministrado o Nitrofurfurilidene na dose diária de 8 a 10 mg por quilo de peso. Aos 10 restantes deu-se placebo. No trans e pós-tratamento não se verificaram alterações nas funções hepática, hematopoiética ou renal de caráter iatrogênico. Xenodiagnóstico e provas sorológicas foram realizadas mensalmente. O xenodiagnóstico, nos 15 doentes tratados, aos 60º dias da fase trans-terapêutica, mostrou-se negativo e assim se manteve durante 4 anos, período de tempo que durou a nossa observação. Quanto às reações sorodiagnósticas o mesmo não ocorreu, embora a partir dos 12 meses do término do tratamento o grupo que recebeu a droga tenha passado a apresentar níveis mais baixos de anticorpos. Os A.A. comentam o desacordo entre os achados do xenodiagnóstico e os das provas sorológicas e sugerem uma hipótese para justificá-lo. Concluem que, embora com menos evidência do que nas formas agudas, o Nitrofurfurilidene revela certa eficácia na fase crônica da infecção chagásica.
Twenty five patients with chronic Chagas' disease were selected presenting positive serology and high parasitaemia. A group of fifteen partients was treated with Nitrofurfurilidene during 120 days with daily doses of 8-10 mg per kg of body weight. The remaining group of ten individuais received only placebo. Yatrogenic alteration of liver, hematopoiesis or kidney were not obseived during or after treatment. Xenodiagnosis of the experimental 15 patient group was negative at the 60th day of treatment and remained so up to 5 years that the observation lasted. Regarding the serum diagnosis the behaviour was not alike eventhough the experimental group presented lower levels of antibodies after the 12th month of the treatment. The authors discuss the disagreement between the xenodiagnosis and serologie results and offer an hypothesis to justify it. They conclude that Nitrofurfurilidene has some efficiency in the chronic phase of Chagas' disease although less evident than in the acute form.
Twenty five patients with chronic Chagas' disease were selected presenting positive serology and high parasitaemia. A group of fifteen partients was treated with Nitrofurfurilidene during 120 days with daily doses of 8-10 mg per kg of body weight. The remaining group of ten individuais received only placebo. Yatrogenic alteration of liver, hematopoiesis or kidney were not obseived during or after treatment. Xenodiagnosis of the experimental 15 patient group was negative at the 60th day of treatment and remained so up to 5 years that the observation lasted. Regarding the serum diagnosis the behaviour was not alike eventhough the experimental group presented lower levels of antibodies after the 12th month of the treatment. The authors discuss the disagreement between the xenodiagnosis and serologie results and offer an hypothesis to justify it. They conclude that Nitrofurfurilidene has some efficiency in the chronic phase of Chagas' disease although less evident than in the acute form.
| Reference Key |
silva1974revistaeficcia
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Newton Neves da Silva;Gisebel Kuhn;João Francisco Cardoso dos Santos;Günther Von Eye;João Aloisio Braga Chaher |
| Journal | mobile information systems |
| Year | 1974 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.