penares sp sponge from menjangan island-water west bali national park: isolation of cytotoxic compounds
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2017
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Abstract
Sponges are multicellular animals which have cytotoxic compounds. In this study, isolation and cytotoxic activity of Penares sp sponge from Menjangan island-water West Bali National Park have been carried out. The results showed that chloroform extract and GF V Penares sp fraction were toxic according to Brine Shrimp Lethality Test method (each 85% and 63.3% mortality at 25μg/mL concentration). The isolation result of GF V fraction was obtained a compound (Spot 4) that is active as cytotoxic agent against T47D cells (IC50 of 12.7 ug/mL). Spot 4 is a terpenoid compound which has conjugated double bonds.
| Reference Key |
setyowati2017majalahpenares
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|---|---|
| Authors | ;Erna Prawita Setyowati;Sudarsono Sudarsono;Retno Murwanti |
| Journal | clinical microbiology reviews |
| Year | 2017 |
| DOI |
10.22146/mot.31547
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| URL | |
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