cellular morphology-mediated proliferation and drug sensitivity of breast cancer cells

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ID: 172784
2017
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Abstract
The interpretation of the local microenvironment of the extracellular matrix for malignant tumor cells is in intimate relation with metastatic spread of cancer cells involving the associated issues of cellular proliferation and drug responsiveness. This study was aimed to assess the combination of both surface topographies (fiber alignments) and different stiffness of the polymeric substrates (poly(l-lactic acid) and poly(ε-caprolactone), PLLA and PCL, respectively) as well as collagen substrates (coat and gel) to elucidate the effect of the cellular morphology on cellular proliferation and drug sensitivities of two different types of breast cancer cells (MDA-MB-231 and MCF-7). The morphological spreading parameter (nucleus/cytoplasm area ratio) induced by the anthropogenic substrates has correlated intimately with the cellular proliferation and the drug sensitivity the half maximal inhibitory concentration (IC50) of cancer cells. This study demonstrated the promising results of the parameter for the evaluation of cancer cell malignancy.
Reference Key
domura2017journalcellular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ryota Domura;Rie Sasaki;Yuma Ishikawa;Masami Okamoto
Journal carbon
Year 2017
DOI
10.3390/jfb8020018
URL
http://www.mdpi.com/2079-4983/8/2/18
Keywords
cellular proliferation drug sensitivity

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