establishment of mui009 – a human induced pluripotent stem cells from a 32 year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2
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2017
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Abstract
The thalassemias are a group of genetic disorders characterized by a deficiency in the synthesis of globin chains. In this study the MUi009-A human induced pluripotent stem cell line was successfully generated from peripheral blood CD34+ haematopoietic progenitors of a 32 year old male who had coinherited a homozygous β°-thalassemia mutation at codon 41/42 (-TCTT) and a heterozygous α-thalassemia 4.2 deletion. The MUi009-A cell line exhibited embryonic stem cell characteristics with consistent pluripotency marker expression and the capability of differentiating into the three germ layers. The cell line may provide a tool for drug testing and gene therapy studies.
| Reference Key |
wongkummool2017stemestablishment
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| Authors | ;Wasinee Wongkummool;Warun Maneepitasut;Pirut Tong-ngam;Amornrat Tangprasittipap;Thongperm Munkongdee;Chanikarn Boonchuay;Saovaros Svasti;Narisorn Kitiyanant;Kittiphong Paiboonsukwong;Suthat Fucharoen;Alisa Tubsuwan |
| Journal | journal of energy chemistry |
| Year | 2017 |
| DOI |
10.1016/j.scr.2017.02.012
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| URL | |
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