metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in nci-h460 human lung cancer cells
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ID: 172679
2013
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Abstract
OBJECTIVE: To test the effectiveness of combining conventional antineoplastic drugs (cisplatin and etoposide) with metformin in the treatment of non-small cell lung cancer in the NCI-H460 cell line, in order to develop new therapeutic options with high efficacy and low toxicity.METHODS: We used the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and calculated the combination index for the drugs studied.RESULTS: We found that the use of metformin as monotherapy reduced the metabolic viability of the cell line studied. Combining metformin with cisplatin or etoposide produced a synergistic effect and was more effective than was the use of cisplatin or etoposide as monotherapy.CONCLUSIONS: Metformin, due to its independent effects on liver kinase B1, had antiproliferative effects on the NCI-H460 cell line. When metformin was combined with cisplatin or etoposide, the cell death rate was even higher.
| Reference Key |
teixeira2013jornalmetformin
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|---|---|
| Authors | ;Sarah Fernandes Teixeira;Isabella dos Santos Guimarães;Klesia Pirola Madeira;Renata Dalmaschio Daltoé;Ian Victor Silva;Leticia Batista Azevedo Rangel |
| Journal | cryobiology |
| Year | 2013 |
| DOI |
10.1590/S1806-37132013000600002
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| URL | |
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