prenylated flavonoids from morus alba l. cause inhibition of g1/s transition in thp-1 human leukemia cells and prevent the lipopolysaccharide-induced inflammatory response

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ID: 172657
2013
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Abstract
Morus alba L. (MA) is a natural source of many compounds with different biological effects. It has been described to possess anti-inflammatory, antioxidant, and hepatoprotective activities. The aim of this study was to evaluate cytotoxicity of three flavonoids isolated from MA (kuwanon E, cudraflavone B, and 4′-O-methylkuwanon E) and to determine their effects on proliferation of THP-1 cells, and on cell cycle progression of cancer cells. Anti-inflammatory effects were also determined for all three given flavonoids. Methods used in the study included quantification of cells by hemocytometer and WST-1 assays, flow cytometry, western blotting, ELISA, and zymography. From the three compounds tested, cudraflavone B showed the strongest effects on cell cycle progression and viability of tumor and/or immortalized cells and also on inflammatory response of macrophage-like cells. Kuwanon E and 4′-O-methylkuwanon E exerted more sophisticated rather than direct toxic effect on used cell types. Our data indicate that mechanisms different from stress-related or apoptotic signaling pathways are involved in the action of these compounds. Although further studies are required to precisely define the mechanisms of MA flavonoid action in human cancer and macrophage-like cells, here we demonstrate their effects combining antiproliferative and anti-inflammatory activities, respectively.
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kollar2013evidence-basedprenylated Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Peter Kollar, Tomáš Bárta, Jan Hošek, Karel Souček, Veronika Müller Závalová, Shushan Artinian, Rabih Talhouk, Karel Šmejkal, Pavel Suchý, Aleš Hampl
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Journal ACS applied materials & interfaces
Year 2013
DOI
10.1155/2013/350519
URL
http://dx.doi.org/10.1155/2013/350519
Keywords
Other systems of medicine

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