aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function

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ID: 172360
2011
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Abstract
Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training.
Reference Key
brum2011brazilianaerobic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;P.C. Brum;A.V.N. Bacurau;A. Medeiros;J.C.B. Ferreira;A.S. Vanzelli;C.E. Negrão
Journal Free radical biology & medicine
Year 2011
DOI
DOI not found
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900002
Keywords
heart failure cardiac remodeling exercise training

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