design and synthesis of isosteviol triazole conjugates for cancer therapy
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ID: 172025
2014
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Abstract
One of the keys for successfully developing drugs against the broad spectrum of cancer cell types is structural diversity. In the current study, we focused on a family of isosteviol derivatives as potential novel antitumor agents. Isosteviol is a tetracyclic diterpenoid obtained by acid hydrolysis of steviol glycoside extracts isolated from abundant Stevia rebaudiana plants. In this work, we have designed and synthesized a panel of isosteviol triazole conjugates using “click” chemistry methodology. Evaluation of these compounds against a series of cancer cell lines derived from primary and metastatic tumors demonstrated that these conjugates exhibit cytotoxic activities with IC50 in the low μM range. In addition, their anti-proliferative activities are cancer cell type specific. Taken together, our studies underscore the importance of structural diversity in achieving cancer cell type specific drug development.
| Reference Key |
khaybullin2014moleculesdesign
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|---|---|
| Authors | ;Ravil N. Khaybullin;Mei Zhang;Junjie Fu;Xiao Liang;Tammy Li;Alan R. Katritzky;Paul Okunieff;Xin Qi |
| Journal | Journal of ethnopharmacology |
| Year | 2014 |
| DOI |
10.3390/molecules191118676
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| URL | |
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