Sphaerostilbellins, New Antimicrobial Aminolipopeptide Peptaibiotics from .
Clicks: 196
ID: 171930
2020
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Emerging Content
4.8
/100
16 views
16 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
is a mycoparasitic fungus that can be found parasitizing wood-decay basidiomycetes in the southern USA. Organic solvent extracts of fermented strains of exhibited potent antimicrobial activity, including potent growth inhibition of human pathogenic yeasts and the respiratory pathogenic fungus , and the Gram-positive bacterium . Bioassay-guided separations led to the purification and structure elucidation of new peptaibiotics designated as sphaerostilbellins A and B. Their structures were established mainly by analysis of NMR and HRMS data, verification of amino acid composition by Marfey's method, and by comparison with published data of known compounds. They incorporate intriguing structural features, including an N-terminal 2-methyl-3-oxo-tetradecanoyl (MOTDA) residue and a C-terminal putrescine residue. The minimal inhibitory concentrations for sphaerostilbellins A and B were measured as 2 μM each for , 1 μM each for , and 4 and 2 μM, respectively, for . Murine macrophage cells were unaffected at these concentrations.
| Reference Key |
perlatti2020sphaerostilbellinsbiomolecules
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Perlatti, Bruno;Nichols, Connie B;Alspaugh, J Andrew;Gloer, James B;Bills, Gerald F; |
| Journal | Biomolecules |
| Year | 2020 |
| DOI |
E1371
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.