Sesquiterpene coumarins from Ferula sinkiangensis K.M.Shen and their cytotoxic activities.

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ID: 171924
2020
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Abstract
Five undescribed sesquiterpene coumarins, one undescribed coumarin derivative, and twenty-five known analogues, were isolated from the resin of Ferula sinkiangensis K.M.Shen. The planar structures and relative configurations of the undescribed compounds were determined by NMR experiment and HRESIMS data. The absolute configurations were established by Electrostatic Circular Dichroism method. Among these analogues, Sinkiangenol E showed the best cytotoxic activity against HeLa cervical cancer cells. Annexin V-FITC/PI staining indicated that Sinkiangenol E induced apoptosis in HeLa cells. Cell cycle analysis showed Sinkiangenol E arrested cell cycle at G0/G1 phase. Western blot results proved that Sinkiangenol E affected apoptosis-related and cell cycle regulation-related protein expression by activating the MAPK pathway.
Reference Key
wang2020sesquiterpenephytochemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Junchi;Wang, Huijuan;Zhang, Meng;Li, Xiaojin;Zhao, Yaqin;Chen, Gang;Si, Jianyong;Jiang, Lin;
Journal Phytochemistry
Year 2020
DOI
S0031-9422(20)31146-8
URL
Keywords
structural elucidation mapk cytotoxic activity apiaceae ferula sinkiangensis k.m.shen sesquiterpene coumarin

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