Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery.

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ID: 17163
2019
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Abstract
A "smart" core@shell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (-) silica layer (-SiO). The GNS@-SiO nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a -SiO layer providing additional non-collapsible space for drug storage. The influence of the -SiO layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The "smart" core@shell composite NPs having a -SiO layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no -SiO shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation.
Reference Key
kim2019hydrogelencapsulatedinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kim, Bo Sang;Chen, Yi-Ting;Srinoi, Pannaree;Marquez, Maria D;Lee, T Randall;
Journal International journal of molecular sciences
Year 2019
DOI
10.3390/ijms20143422
URL
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678574/
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