Adaptive control in lubrication, adhesion, and hemostasis by Chitosan-Catechol-pNIPAM.

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ID: 17161
2019
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Abstract
Bio-inspired wet adhesives attract considerable attention in the biomedical field. However, achieving reversible and controllable wet adhesion still remains a challenging issue. In this study, we report a new thermo-responsive polysaccharide wet adhesive conjugate named Chitosan-Catechol-poly(N-isopropyl acrylamide) (Chitosan-Catechol-pNIPAM), where catechol, the wet adhesive moiety, and pNIPAM, the thermal responsive group, are chemically tethered to a chitosan backbone. The as-synthesized Chitosan-Catechol-pNIPAM presents a reversible sol-gel transition behavior when the temperature is cycled below and above the lower critical solution temperature (LCST, 35 °C), along with dynamic switching between lubrication and wet adhesion on various materials. Based on these excellent features, Chitosan-Catechol-pNIPAM can realize controllable attachment/detachment behavior over the skin through heating/cooling processes. Due to its good biocompatibility, the Chitosan-Catechol-pNIPAM coated syringe needles exhibit instant hemostasis after removing the needles from the punctured sites of mouse veins. Overall, the as-synthesized Chitosan-Catechol-pNIPAM is expected to be used as a new intelligent adhesive in various biomedical settings.
Reference Key
xu2019adaptivebiomaterials Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Xu, Rongnian;Ma, Shuanhong;Wu, Yang;Lee, Haeshin;Zhou, Feng;Liu, Weimin;
Journal Biomaterials science
Year 2019
DOI
10.1039/c9bm00697d
URL
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