Thermoresponsive Forming Hydrogel with Sol-Gel Irreversibility for Effective Methicillin-Resistant Infected Wound Healing.

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ID: 17148
2019
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Abstract
An forming hydrogel has emerged as a promising wound dressing recently. As physically cross-linked hydrogels are normally unstable, most forming hydrogels are chemically cross-linked. However, big concerns have remained regarding the slow gelation and the potential toxicity of residual functional groups from cross-linkers or the polymer matrix. Herein, we report a sprayable forming hydrogel composed of poly(-isopropylacrylamide---butyl acrylate)-poly(ethylene glycol)-poly(-isopropylacrylamide---butyl acrylate) copolymer (P(NIPAM--nBA)-PEG-P(NIPAM--nBA), denoted as PEP) and silver-nanoparticles-decorated reduced graphene oxide nanosheets (Ag@rGO, denoted as AG) in response to skin temperature. This thermoresponsive hydrogel exhibits intriguing sol-gel irreversibility at low temperatures for the stable dressing of a wound, which is attributed to the inorganic/polymeric dual network and abundant coordination interactions between Ag@rGO nanosheets and PNIPAM. The biocompatibility and antibacterial ability against methicillin-resistant (MRSA) of this PEP-AG hydrogel wound dressing are confirmed and , which could transparently promote the healing of a MRSA-infected skin defect.
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yan2019thermoresponsiveacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yan, Xu;Fang, Wei-Wei;Xue, Jingzhe;Sun, Tian-Ci;Dong, Liang;Zha, Zhengbao;Qian, Haisheng;Song, Yong-Hong;Zhang, Min;Gong, Xinglong;Lu, Yang;He, Tao;
Journal acs nano
Year 2019
DOI
10.1021/acsnano.9b02845
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