dendritic cells in systemic lupus erythematosus: from pathogenic players to therapeutic tools

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ID: 171280
2016
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Abstract
System lupus erythematosus (SLE) is a multifactorial systemic autoimmune disease with a wide variety of presenting features. SLE is believed to result from dysregulated immune responses, loss of tolerance of CD4 T cells and B cells to ubiquitous self-antigens, and the subsequent production of anti-nuclear and other autoreactive antibodies. Recent research has associated lupus development with changes in the dendritic cell (DC) compartment, including altered DC subset frequency and localization, overactivation of mDCs and pDCs, and functional defects in DCs. Here we discuss the current knowledge on the role of DC dysfunction in SLE pathogenesis, with the focus on DCs as targets for interventional therapies.
Reference Key
klarquist2016mediatorsdendritic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jared Klarquist, Zhenyuan Zhou, Nan Shen, Edith M. Janssen
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Journal polyhedron
Year 2016
DOI
10.1155/2016/5045248
URL
http://dx.doi.org/10.1155/2016/5045248
Keywords
pathology

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