conjugated quantum dots inhibit the amyloid β (1–42) fibrillation process
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ID: 171246
2011
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Abstract
Nanoparticles have
enormous potential in diagnostic and therapeutic
studies. We have demonstrated that the amyloid
beta mixed with and conjugated to dihydrolipoic
acid- (DHLA) capped CdSe/ZnS quantum dots (QDs)
of size approximately 2.5 nm can be used
to reduce the fibrillation process. Transmission
electron microscopy (TEM) and atomic force
microscopy (AFM) were used as tools for analysis
of fibrillation. There is a significant change
in morphology of fibrils when amyloid β (1–42) (Aβ (1–42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs.
| Reference Key |
thakur2011internationalconjugated
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|---|---|
| Authors | ;Garima Thakur;Miodrag Micic;Yuehai Yang;Wenzhi Li;Dania Movia;Silvia Giordani;Hongzhou Zhang;Roger M. Leblanc |
| Journal | advanced biomedical research |
| Year | 2011 |
| DOI |
10.4061/2011/502386
|
| URL | |
| Keywords |
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