the role of ghrelin in anorexia nervosa

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ID: 171222
2018
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Abstract
Ghrelin, a 28-amino acid peptide hormone expressed in X/A-like endocrine cells of the stomach, is the only known peripherally produced and centrally acting peptide that stimulates food intake and therefore attracted a lot of attention with one major focus on the treatment of conditions where an increased energy intake or body weight gain is desired. Anorexia nervosa is an eating disorder characterized by a pronounced reduction of body weight, a disturbed body image and hormonal alterations. Ghrelin signaling has been thoroughly investigated under conditions of anorexia nervosa. The present review will highlight these alterations of ghrelin in anorexia and discuss possible treatment strategies targeting ghrelin signaling. Lastly, gaps in knowledge will be mentioned to foster future research.
Reference Key
schalla2018internationalthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Martha A. Schalla;Andreas Stengel
Journal Intertax
Year 2018
DOI
10.3390/ijms19072117
URL
http://www.mdpi.com/1422-0067/19/7/2117
Keywords
body weight animal model drug metabolism hunger gut-brain axis food intake eating disorder hormone brain-gut axis

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