high throughput fish analysis: a new, sensitive option for evaluation of hematological malignancies
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ID: 170798
2013
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Abstract
OBJECTIVE: The aim of this study was to determine the efficiency of the high throughput FISH analysis (HTFA) method for detecting genetic alterations in hematological malignancies, which is a new bacterial artificial chromosome array-based approach.
METHODS: We performed a HTFA study of bone marrow aspiration and peripheral blood samples of 77 cases (n=19 myelodysplastic syndrome, n=17 acute lymphoblastic leukemia, n=9 chronic myeloid leukemia, n=32 acute myeloid leukemia) with hematological malignancies during the periods of initial diagnosis, treatment, and/or follow-up.
RESULTS: Both numerical and structural abnormalities were detected by HTFA. We observed aberrations in 88% of our acute lymphoblastic leukemia patients, 25% of acute myeloid leukemia patients, and 31% of myelodysplastic syndrome patients. In chronic myeloid leukemia cases, aberration was not detected by HTFA.
CONCLUSION: Our results showed that HTFA, combined with other methods, will gradually take a place in the routine diagnosis of hematologic malignancies.
| Reference Key |
savl2013turkishhigh
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| Authors | ;Hakan Savlı;Seda Eren;Nilüfer Üzülmez;Zeynep İlkay;Duygu Yavuz;Deniz Sünnetçi;Abdullah Hacıhanifioğlu;Naci Çine |
| Journal | proceedings of the international conference on iot in social, mobile, analytics and cloud, i-smac 2017 |
| Year | 2013 |
| DOI |
10.4274/Tjh.2012.0033
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| URL | |
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