effect of nigella sativa on ischemia-reperfusion induced rat kidney damage
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ID: 170697
2015
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Abstract
Objective(s):There are a few previously reported studies about the effect of Nigella sativa oil on renal ischemia-reperfusion injury (IRI). The aim of the present study was to test the hypothesis whether pre- or post-treatment with N. sativa hydroalcoholic extract (NSE) would reduce tissue injury and oxidative damages in a clinically relevant rat model of renal IRI. Materials and Methods: IRI was induced by clamping of bilateral renal arteries for 40 min fallowed by reperfusion for 180 min. NSE was prepared in a Soxhlet extractor and administrated with doses of 150 mg/kg or 300 mg/kg at 1 hr before ischemia induction (P-150 and 300) or at the beginning of reperfusion phase (T-150 and 300), via jugular catheter intravenously. The kidneys were then removed and subjected to biochemical analysis, comet assay or histopathological examination. Results: The kidneys of untreated IRI rats had a higher histopathological score (P
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havakhah2015iranianeffect
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| Authors | ;Shahrzad Havakhah;Hamid R Sadeghnia;Mosa-Al-Reza Hajzadeh;Nama Mohammadian Roshan;Somayeh Shafiee;Hossein Hosseinzadeh;Narges Mohareri;Abolfazl Khajavi Rad |
| Journal | PloS one |
| Year | 2015 |
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