determination of eye irritation potential of low-irritant products: comparison of in vitro results with the in vivo draize rabbit test

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ID: 170389
2012
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Abstract
In an attempt to build the evaluation strategies to assess the human eye irritation, a reassessment of some in vitro tests is necessary, particularly concerning the non-irritants, mild and moderate irritants. Thus, the correlations between results obtained from the Draize test with the in vitro methods HET-CAM (Hens Egg Test-Chorion Allantonic Membrane) and RBC haemolysis assay to assess the ocular irritancy potential of 20 eye drops were examined. Parameters such as accuracy (%) and specificity (%) were determined. All results were correlated with RBC correctly with the results obtained in the Draize test. The HET-CAM presented four false-positive results, showing a tendency of data overestimation. Despite the high specificity provided mainly by the RBC, it would be necessary to test a wider range of products representing all the scales of irritation to confirm its ability to be used as a first alternative to test products that could be presumptive non-irritants.
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Authors ;Andréa Martins da Nóbrega;Eloisa Nunes Alves;Rosaura de Farias Presgrave;Rodrigo Netto Costa;Isabella Fernandes Delgado
Journal current drug delivery
Year 2012
DOI
10.1590/S1516-89132012000300008
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000300008
Keywords
alternative methods

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