pomolic acid ameliorates fibroblast activation and renal interstitial fibrosis through inhibition of smad-stat signaling pathways

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ID: 170279
2018
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Abstract
Fibrosis is a common pathological feature in most kinds of chronic kidney disease. Transforming growth factor β1 (TGF-β1) signaling is the master pathway regulating kidney fibrosis pathogenesis, in which mothers against decapentaplegic homolog 3 (SMAD3) with signal transducer and activator of transcription 3 (STAT3) act as the integrator of various pro-fibrosis signals. We examine the effects of pomolic acid (PA) on mice with unilateral ureteral obstruction (UUO) and TGF-β1 stimulated kidney fibroblast cells. UUO mice were observed severe tubular atrophy, and tubulointerstitial fibrosis and extracellular matrix (ECM) deposition at seven days postoperatively. However, PA-treated UUO mice demonstrated only moderate injury, minimal fibrosis, and larger reductions in the expression of ECM protein and epithelial-mesenchymal transition (EMT) progress. PA inhibited the SMAD-STAT phosphorylation in UUO mice. PA effects were also confirmed in TGF-β1 stimulated kidney fibroblast cells. In this study, we first demonstrated that PA ameliorates fibroblast activation and renal interstitial fibrosis. Our results indicate that PA may be useful as a potential candidate in the prevention of chronic kidney disease.
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park2018moleculespomolic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ji-Hyun Park, Kyung Mi Jang, Hyun Jin An, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyemin Gu, Byoungduck Park, Kwan-Kyu Park
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Journal Journal of ethnopharmacology
Year 2018
DOI
10.3390/molecules23092236
URL
http://www.mdpi.com/1420-3049/23/9/2236
Keywords
tgf-β1 fibroblast

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