tyrosine kinase inhibitor induced isolated pericardial effusion

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ID: 169916
2015
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Ranked #53 of 83 articles by views in multi-span large bridges - proceedings of the international conference on multi-span large bridges, 2015

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Abstract
Long-term therapy with tyrosine kinase inhibitors (TKI) has resulted in improved outcomes for patients suffering from Bcr-Abl fusion protein-harboring leukemias. As a result, a growing population of patients on TKI therapy present to their primary care providers. In this case, we report on the case of a 62-year-old male who presented with a symptomatic pericardial effusion. After pericardiocentesis, malignancy and infectious etiologies were excluded. The pericardial effusion was attributed to his TKI, with a transition of this medication to a different TKI. A repeat evaluation 1 month following the withdrawal of the offending agent showed no recurrence of his pericardial effusion on echocardiogram. In this report, we will highlight a rare but important side effect of TKI therapy before discussing its purported mechanisms and differing incidence rates. Early recognition of serosal inflammation related to long-term TKI therapy by primary care providers is important in preventing patient morbidity and mortality.
Reference Key
agrawal2015casetyrosine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Vineet Agrawal;Eric S. Christenson;Margaret M. Showel
Journal multi-span large bridges - proceedings of the international conference on multi-span large bridges, 2015
Year 2015
DOI
10.1159/000375484
URL
http://www.karger.com/Article/FullText/375484
Keywords
Tyrosine kinase inhibitor Oncology including cancer and carcinogens tumors

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