frequency of ccr5delta32 in brazilian populations
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ID: 169803
2006
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Abstract
A sample of 103 randomly chosen healthy individuals from Alegrete, RS, Brazil, was tested for the CCR5delta32 allele, which is known to influence susceptibility to HIV-1 infection. The CCR5delta32 allele was identified by PCR amplification using specific primers flanking the region of deletion, followed by electrophoresis on a 3% agarose gel. The data obtained were compared to those reported for other populations and interpreted in terms of Brazilian history. The individuals studied came from a highly admixed population. Most of them were identified as white (N = 59), while blacks and browns (mulattoes) were N = 13 and N = 31, respectively. The observed frequencies, considering the white, black and brown samples (6.8, 3.8, and 6.4%, respectively), suggest an important European parental contribution, even in populations identified as black and brown. However, in Brazil as a whole, this allele shows gradients indicating a relatively good correlation with the classification based on skin color and other physical traits, used here to define major Brazilian population groups.
| Reference Key |
vargas2006brazilianfrequency
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|---|---|
| Authors | ;A.E. Vargas;A.R. Marrero;F.M. Salzano;M.C. Bortolini;J.A.B. Chies |
| Journal | Free radical biology & medicine |
| Year | 2006 |
| DOI |
10.1590/S0100-879X2006000300002
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