the association between adiposity and the risk of glaucoma: a meta-analysis

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2017
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Abstract
Purpose. This meta-analysis was conducted to determine the potential association between adiposity and glaucoma incidence. Materials and Methods. A comprehensive literature search was performed in PubMed and ISI Web of Science. A meta-analysis was conducted using STATA software. Results. Fifteen eligible studies involving 2,445,980 individuals were included to investigate the association between adiposity and glaucoma incidence. The relative risks (RRs) were pooled with 95% confidence intervals (CI) by using a random-effects model. The pooled RR between adiposity and elevated intraocular pressure (IOP) was 1.73 (95% CI, 1.18–2.54), whereas that between adiposity and open-angle glaucoma (OAG) was 0.97 (95% CI, 0.83–1.13). The pooled RR between abdominal adiposity and glaucoma was 1.28 (95% CI, 1.15–1.41), whereas that between general adiposity and glaucoma was 1.09 (95% CI, 0.87–1.37). Results of subgroup analysis by sex indicated the association between adiposity and glaucoma in the female group (RR, 1.31; 95% CI, 1.05–1.64), but not in the male group (RR, 1.11; 95% CI, 0.77–1.60). The pooled RR of cohort studies and cross-sectional studies were 1.00 (95% CI, 0.84–1.20) and 1.22 (95% CI, 0.89–1.66), respectively. Conclusions. Adiposity has a higher risk of elevated IOP, and abdominal adiposity has a positive association with glaucoma, especially in female patients.
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Authors ;Weiming Liu;Jiawen Ling;Yiyi Chen;Yan Wu;Peirong Lu
Journal chemical reviews
Year 2017
DOI
10.1155/2017/9787450
URL
http://dx.doi.org/10.1155/2017/9787450
Keywords
Hypoxia Technology (General) ophthalmology oxidative stress antioxidant activities panax ginseng optical fiber hardware-in-the-loop simulation light clinical endocrinology diseases of the endocrine glands immunologic diseases allergy sportssports medicine

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