a multi-functional nanoplatform for efficacy tumor theranostic applications

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ID: 169321
2017
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Abstract
Nanomaterials with multiple functions have become more and more popular in the domain of cancer research. MoS2 has a great potential in photothermal therapy, X-ray/CT imaging and drug delivery. In this study, a water soluble MoS2 nanosystem (MoS2-PEG) was synthesized and explored in drug delivery, photothermal therapy (PTT) and X-ray imaging. Doxorubicin (DOX) was loaded onto MoS2-PEG with a high drug loading efficiency (~69%) and obtained a multifunctional drug delivery system (MoS2-PEG/DOX). As the drug delivery, MoS2-PEG/DOX could efficiently cross the cell membranes, and escape from the endosome via NIR light irradiation, lead to more apoptosis in MCF-7 cells, and afford higher antitumor efficacy without obvious toxic effects to normal organs owing to its prolonged blood circulation and 11.6-fold higher DTX uptake of tumor than DOX. Besides, MoS2-PEG/DOX not only served as a drug delivery system, but also as a powerful PTT agent for thermal ablation of tumor and a strong X-ray contrast agent for tumor diagnosis. In the in vitro and in vivo studies, MoS2-PEG/DOX exhibited excellent tumor-targeting efficacy, outstanding synergistic anti-cancer effect of photothermal and chemotherapy and X-ray imaging property, demonstrating that MoS2-PEG/DOX had a great potential for simultaneous diagnosis and photothermal-chemotherapy in cancer treatment.
Reference Key
shi2017asiana Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jinjin Shi;Hongling Zhang;Zhaoyang Chen;Lihua Xu;Zhenzhong Zhang
Journal topics in organometallic chemistry
Year 2017
DOI
10.1016/j.ajps.2016.12.001
URL
http://www.sciencedirect.com/science/article/pii/S181808761630263X
Keywords
bio-imaging endosome escape pharmacology

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