chlorogenic acid protects against cholestatic liver injury in rats

Clicks: 231
ID: 169267
2015
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Abstract
The aim of this study was to investigate the protective effect of chlorogenic acid (CA) on liver injury caused by bile duct ligation (BDL), as well as the potential mechanism. Permanent bile duct ligation induced liver injury was evaluated by liver index, liver function and pathological observation. Oral administration of CA for 3 weeks markedly attenuated liver swelling and fibrosis. Blood biochemistry results revealed that CA decreased alanine transaminase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, direct bilirubin and total bile acid. PCR analysis indicated that collagen I, collagen III, transforming growth factor and vascular endothelial growth factor mRNA were increased markedly by BDL treatment but these increases were suppressed by CA. Additionally, CA effectively alleviated the expression of α-smooth muscle actin induced by BDL. Taken together, our data indicate that CA can efficiently inhibit BDL-induced liver injury in rats, which is a candidate drug for preventing liver injury against cholestasis.
Reference Key
wu2015journalchlorogenic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Duohu Wu;Chuanyu Bao;Longhe Li;Mingliang Fu;Desen Wang;Jinyuan Xie;Xiaoguang Gong
Journal plant direct
Year 2015
DOI
10.1016/j.jphs.2015.10.005
URL
http://www.sciencedirect.com/science/article/pii/S1347861315002091
Keywords
chlorogenic acid pharmacology

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