serum paraoxonase-1 activities and malondialdehyde levels in patients with epilepsy
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2012
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Abstract
Objectives: We aimed to evaluate antioxidant paraoxonase-1 (PON-1) activity together with malondialdehyde(MDA) (an oxidative stress parameter) levels in patientswith epilepsy.Materials and methods: Forty-five epilepsy patientswere included in the study and compared with healthycontrols (n = 45). The levels of serum MDA and PON-1activities were measured by the Ohkawa method and theEckerson method, respectively.Results: Serum MDA level was significantly higher (P =0.015), whereas PON-1 activity was sigificantly lower (P =0.011) in the patient group than the controls.Conclusions: Increased reactive oxygen species levelsin epilepsy may result in a oxidative stress, which in turncould result in decreased antioxidant PON-1 activity andincreased MDA levels.Key words: Epilepsy, oxidative stress, malondialdehyde,paraoxonase-1
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| Reference Key |
evik2012dicleserum
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| Authors | ;Mehmet Uğur Çevik;Sefer Varol;Yavuz Yücel;Eşref Akıl;Tahsin Çelepkolu;Adalet Arıkanoğlu;Hatice Yüksel;Mehmet Ufuk Aluçlu |
| Journal | journal of sulfur chemistry |
| Year | 2012 |
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