chitosan and kappa-carrageenan vaginal acyclovir formulations for prevention of genital herpes. in vitro and ex vivo evaluation

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ID: 168974
2015
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Abstract
Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Polysaccharides, such as chitosan and carrageenan, which have good binding capacity with mucosal tissues, are now included in vaginal delivery systems. Marine polymer-based vaginal mucoadhesive solid formulations have been developed for the controlled release of acyclovir, which may prevent the sexual transmission of the herpes simplex virus. Drug release studies were carried out in two media: simulated vaginal fluid and simulated vaginal fluid/simulated seminal fluid mixture. The bioadhesive capacity and permanence time of the bioadhesion, the prepared compacts, and compacted granules were determined ex vivo using bovine vaginal mucosa as substrate. Swelling processes were quantified to confirm the release data. Biocompatibility was evaluated through in vitro cellular toxicity assays, and the results showed that acyclovir and the rest of the materials had no cytotoxicity at the maximum concentration tested. The mixture of hydroxyl-propyl-methyl-cellulose with chitosan- or kappa-carrageenan-originated mucoadhesive systems that presented a complete and sustained release of acyclovir for a period of 8–9 days in both media. Swelling data revealed the formation of optimal mixed chitosan/hydroxyl-propyl-methyl-cellulose gels which could be appropriated for the prevention of sexual transmission of HSV.
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Authors ;María-Pilar Sánchez-Sánchez;Araceli Martín-Illana;Roberto Ruiz-Caro;Paulina Bermejo;María-José Abad;Rubén Carro;Luis-Miguel Bedoya;Aitana Tamayo;Juan Rubio;Anxo Fernández-Ferreiro;Francisco Otero-Espinar;María-Dolores Veiga
Journal jixie gongcheng xuebao/journal of mechanical engineering
Year 2015
DOI
10.3390/md13095976
URL
http://www.mdpi.com/1660-3397/13/9/5976
Keywords
Cytotoxicity chitosan genital herpes ex vivo bioadhesionbiology (general)

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