antidiarrheal activity of dissotis multiflora (sm) triana (melastomataceae) leaf extract in wistar rats and subacute toxicity evaluation
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2017
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Abstract
The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D. multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S. flexneri to rats. Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg. The level of biochemical parameters was assessed and organs histology examined by 14 days’ subacute toxicity. S. flexneri stool load decreased significantly in dose-dependent manner. The level of ALT increased (p<0.05) in male rats treated with the dose of 445.68 mg/kg while creatinine level increased in rats treated with both doses. In female rats, a significant decrease (p<0.05) of the level of AST and creatinine was noted in rats treated with the dose of 222.84 mg/kg of D. multiflora. Histological exams of kidney and liver of treated rats showed architectural modifications at the dose of 445.68 mg/kg. This finding suggests that D. multiflora leaf extract is efficient against diarrhea caused by S. flexneri but the treatment with doses lower than 222.84 mg/kg is recommended while further study is required to define the exact efficient nontoxic dose.
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| Reference Key |
afagnigni2017evidence-basedantidiarrheal
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|---|---|
| Authors | ;Alian Désiré Afagnigni;Maximilienne Ascension Nyegue;Chantal Florentine Ndoye Foe;Youchahou Njankouo Ndam;Frédéric Nico Njayou;Marie Christine Fonkoua;François-Xavier Etoa |
| Journal | ACS applied materials & interfaces |
| Year | 2017 |
| DOI |
10.1155/2017/4038371
|
| URL | |
| Keywords |
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