redox responses in patients with sepsis: high correlation of thioredoxin-1 and macrophage migration inhibitory factor plasma levels
Clicks: 120
ID: 168525
2010
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
120 views
8 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #320 of 382 articles by views in polyhedron
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 382 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process.
Materials and Methods. Blood samples from patients with severe sepsis or septic shock (n=15) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers (n=18) were collected once; samples from postoperative patients (n=28) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF.
Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: rsp=0.720,ρ=0.698/t24: rsp=0.771,ρ=0.949).
Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response.
| Reference Key |
brenner2010mediatorsredox
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Thorsten Brenner;Claudia Rosenhagen;Jochen Steppan;Christoph Lichtenstern;Jürgen Weitz;Thomas Bruckner;Eike O. Martin;Ursula Hoffmann;Markus A. Weigand;Stefan Hofer |
| Journal | polyhedron |
| Year | 2010 |
| DOI |
10.1155/2010/985614
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.