the relationship between p2x4 and p2x7: a physiologically important interaction?

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ID: 168445
2013
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Abstract
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron. There are many studies demonstrating the importance of the P2Y2 receptor on kidney function, and other P2 receptors are now emerging as participants in renal regulation. The P2X4 receptor has been linked to epithelial sodium transport in the nephron and expression levels of the P2X7 receptor are up-regulated in certain pathophysiological states. P2X7 antagonism has been shown to ameliorate rodent models of DOCA salt-induced hypertension and P2X4 null mice are hypertensive. Interestingly, polymorphisms in the genetic loci of P2X4 and P2X7 have been linked to blood pressure variation in human studies. In addition to the increasing evidence linking these two P2X receptors to renal function and health, a number of studies link the two receptors in terms of physical associations between their subunits, demonstrated both in vitro and in vivo. This review will analyze the current literature regarding interactions between P2X4 and P2X7 and assess the potential impact of these with respect to renal function.
Reference Key
ecraigie2013frontiersthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Eilidh eCraigie;Rebecca E Birch;Robert John Unwin;Scott S Wildman
Journal Journal of clinical and experimental dentistry
Year 2013
DOI
10.3389/fphys.2013.00216
URL
http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00216/full
Keywords
kidney purinergic signaling heterotrimerphysiology

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