tuberculosis risk-associated single nucleotide polymorphisms do not show association with leprosy in chinese population

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ID: 168427
2015
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Abstract
Objective: Leprosy and tuberculosis (TB) are chronic granulomatous infectious diseases. As well as pathogen and environmental factors, host genetic factors make a substantial contribution to susceptibility to both diseases. More importantly, leprosy and TB also have pathogenic mechanisms and clinical features in common. In this study, the genetic association between leprosy and TB was investigated in a Chinese Han population. Methods: A genetic association study that included 46 TB susceptibility single nucleotide polymorphisms (SNPs) was performed, involving 1150 leprosy cases and 1150 controls from the Chinese Han population. The Sequenom MassARRAY system was used. Results: No significant association was found between the 46 SNPs and leprosy. Therefore, according to the present study, there is no shared susceptibility locus between leprosy and TB in the Chinese Han population. Conclusions: Although leprosy and TB have a number of similar characteristics, no shared susceptibility loci were found in the Chinese Han population. Thus, this study demonstrated that the genetic basis of the pathogenesis of the two diseases may vary greatly.
Reference Key
wang2015internationaltuberculosis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Chuan Wang;Na Wang;Yongxiang Yu;Gongqi Yu;Zhenzhen Wang;Xi’an Fu;Hong Liu;Furen Zhang
Journal israel journal of chemistry
Year 2015
DOI
10.1016/j.ijid.2015.03.015
URL
http://www.sciencedirect.com/science/article/pii/S1201971215000764
Keywords
tuberculosis genetic association leprosy chinese han populationinfectious and parasitic diseases

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