simple, rapid and reliable preparation of [<sup>11</sup>c]-(+)-a-dtbz of high quality for routine applications

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ID: 168058
2012
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Abstract
[<sup>11</sup>C]-(+)-a-DTBZ has been used as a marker of dopaminergic terminal densities in human striatum and expressed in islet beta cells in the pancreas. We aimed to establish a fully automated and simple procedure for the synthesis of [<sup>11</sup>C]-(+)-a-DTBZ for routine applications. [<sup>11</sup>C]-(+)-a-DTBZ was synthesized from a 9-hydroxy precursor in acetone and potassium hydroxide with [<sup>11</sup>C]-methyl triflate and was purified by solid phase extraction using a Vac tC-18 cartridge. Radiochemical yields based on [<sup>11</sup>C]-methyl triflate (corrected for decay) were 82.3% ± 3.6%, with a specific radioactivity of 60 GBq/mmol. Time elapsed was less than 20 min from end of bombardment to release of the product for quality control.
Reference Key
tian2012moleculessimple, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jiahe Tian;Xiaojun Zhang;Yungang Li;Jinming Zhang
Journal Journal of ethnopharmacology
Year 2012
DOI
10.3390/molecules17066697
URL
http://www.mdpi.com/1420-3049/17/6/6697
Keywords
automated synthesisorganic chemistry

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