nanoparticle-based delivery of rnai therapeutics: progress and challenges

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ID: 167348
2013
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Abstract
RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the development of safe and effective delivery systems. Inspired by the immense progress with nanotechnology in drug delivery, efforts have been dedicated to the development of nanoparticle-based RNAi delivery systems. For example, a precisely engineered, multifunctional nanocarrier with combined passive and active targeting capabilities may address the delivery challenges for the widespread use of RNAi as a therapy. Therefore, in this review, we introduce the major hurdles in achieving efficient RNAi delivery and discuss the current advances in applying nanotechnology-based delivery systems to overcome the delivery hurdles of RNAi therapeutics. In particular, some representative examples of nanoparticle-based delivery formulations for targeted RNAi therapeutics are highlighted.
Reference Key
burnett2013pharmaceuticalsnanoparticle-based Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;John C. Burnett;John J. Rossi;Jiehua Zhou;Ka-To Shum
Journal journal of cerebral blood flow and metabolism
Year 2013
DOI
10.3390/ph6010085
URL
http://www.mdpi.com/1424-8247/6/1/85
Keywords
passive and active targetingpharmacy and materia medica

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